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- Title
Tocilizumab for the fifth progression of cystic childhood craniopharyngioma--a case report.
- Authors
de Vos-Kerkhof, Evelien; Buis, Dennis R.; Lequin, Maarten H.; Bennebroek, Carlien A.; Aronica, Eleonora; Hulleman, Esther; Zwaveling-Soonawala, Nitash; van Santen, Hanneke M.; Schouten-van Meeteren, Antoinette Y. N.
- Abstract
We present the case of a 15-year-old girl, with a fifth cystic progression of an adamantinomatous craniopharyngioma after multiple surgeries and previous local radiotherapy. She had severe visual impairment, panhypopituitarism including diabetes insipidus, and several components of hypothalamic damage, including morbid obesity and severe fatigue. To prevent further late effects hampering her quality of survival, she was treated biweekly with intravenous tocilizumab, an anti-interleukin-6 agent, which stabilized the cyst for a prolonged time. Based on the biology of adamantinomatous craniopharyngioma, this immune-modulating treatment seems promising for the treatment of this cystic tumor in order to reduce surgery and delay or omit radiotherapy.
- Subjects
CRANIOPHARYNGIOMA; DIABETES insipidus; TOCILIZUMAB; MORBID obesity; VISION disorders; LOW vision
- Publication
Frontiers in Endocrinology, 2023, p1
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2023.1225734