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- Title
In silico design, docking, and synthesis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.
- Authors
Arunkumar, S.; Ramalakshmi, N.; Banu Priya, S.; Hemalatha, B.; Mani Megalai, P.; Padma, K.; Jayashree, S.
- Abstract
In the present work, the docking studies were performed for the proposed compounds against 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase. All the proposed compounds showed nice docking score. The synthesis serine compounds with azetidinone nucleus were carried out. These compounds were expected to show antihyperlipidemic activity from the literature review. The compounds prepared by refluxing serine with different substituted aldehydes give an intermediate Schiff bases (1a-1f) which on treatment with chloroacetyl chloride give substituted azetidinones (2a-2f). The structure of the compounds was confirmed by spectral data. The final synthesized compounds act as a potent HMG-CoA reductase inhibitor. Furthermore, the azetidinone nucleus serves as a synergist by inhibiting the cholesterol absorption from the intestine.
- Subjects
REDUCTASE inhibitors; ALDEHYDE analysis; LACTAM derivatives; CHOLESTEROL; ANTI-infective agents
- Publication
Drug Invention Today, 2018, Vol 10, Issue 12, p2568
- ISSN
0975-7619
- Publication type
Article