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- Title
Deep-brain stimulation in the subthalamic nuclei improves balance performance in patients with Parkinson's disease, when tested without anti-parkinsonian medication.
- Authors
Nilsson, M. H.; Törnqvist, A. L.; Rehncrona, S.
- Abstract
Nilsson MH, Törnqvist AL, Rehncrona S. Deep-brain stimulation in the subthalamic nuclei improves balance performance in patients with Parkinson's disease, when tested without anti-parkinsonian medication. Acta Neurol Scand 2005: 111: 301–308.© Blackwell Munksgaard 2005. To evaluate the effect of bilateral deep-brain stimulation (DBS) in the subthalamic nucleus (STN) on balance performance in patients with severe Parkinson's disease (PD), when tested without anti-parkinsonian medication. Thirty-one patients (median age 65 years, range 50–77) were included. Assessments were made after 10–12 h withdrawal of medication, before and 6 and 12 months after surgery. Postoperative evaluations were performed with DBS on and off. Balance performance was evaluated with the Berg Balance Scale (BBS). Motor symptoms and postural stability (item 30) were assessed with the Unified Parkinson's Disease Rating Scale (UPDRS III). DBS in STN improved balance performance as well as postural stability and motor symptoms significantly ( P ≤ 0.001). Seventy per cent of the patients improved their total score of the BBS with DBS on compared with DBS off. Thus, at 6 months their median improvement was 6 points (q1–q3, 4–11) and at 12 months 4 points (2.5–16). DBS in STN improves balance performance in patients with severe PD.
- Subjects
BRAIN stimulation; BRAIN function localization; CELL nuclei; PATIENTS; PARKINSON'S disease; DRUGS; ANTIPARKINSONIAN agents
- Publication
Acta Neurologica Scandinavica, 2005, Vol 111, Issue 5, p301
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1111/j.1600-0404.2005.00394.x