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- Title
Requirement for the Second Coding Exon of Tat in the Optimal Replication of Macrophage-Tropic HIV-1.
- Authors
Neuveut, Christine; Scoggins, Robert M.; Camerini, David; Markham, Richard B.; Kuan-Teh Jeang
- Abstract
HIV-1 Tat is essential for virus replication and is a potent transactivator of viral gene expression. Evidence suggests that Tat also influences virus infectivity and cytopathicity. Here, we find that the second coding exon of Tat contributes a novel function for the replication/infectivity of macrophage-tropic HIV-1. We show that macrophage-tropic HIV-1 which expresses the full-length two-exon form of Tat replicates better in monocyte-derived macrophages (MDM) than an otherwise isogenic virus which expresses only the one-exon form of Tat. Similarly, two-exon Tat expressing HIV-1 also replicates better than one-exon Tat expressing HIV-1 in two different models of human cells/tissue reconstituted SCID mice.Copyright © 2003 National Science Council, ROC and S. Karger AG, Basel
- Subjects
GENETIC code; HIV; AIDS; TROPISMS; EXONS (Genetics); MACROPHAGES
- Publication
Journal of Biomedical Science, 2003, Vol 10, Issue 6, p651
- ISSN
1021-7770
- Publication type
Article
- DOI
10.1007/BF02256316