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- Title
女童全身体脂比率与性早熟的关系.
- Authors
王凌霄; 程若倩; 章淼滢; 李晓静; 奚立; 郑章乾; 罗飞宏
- Abstract
Objective To study the association of body fat ratio with precocious puberty in girls. Previous studies have shown that body mass index (BMI) is associated with the girls' age of puberty but have not revealed the association of body fat ratio with age of puberty. Methods Based on the consensus on the diagnosis and treatment of central precocious puberty (CPP), 128 children with precocious puberty who were admitted to the hospital from July to August, 2017, were divided into a CPP group with 87 children and a peripheral precocious puberty (PPP) group with 41 children. A total of 51 girls without any puberty development signs were enrolled as the control group. Dual-energy X-ray absorptiometry was used to measure the body fat ratios of upper limbs, legs, trunk, android area, gynoid area, and the whole body. The association between body fat ratios and precocious puberty was analyzed with reference to age, BMI, BMI-Z score, bone age, ovarian volume, and hormone levels. Results Compared with the control group, the CPP and PPP groups had significantly higher body fat ratios of upper limbs, legs, trunk, android area, gynoid area, and the whole body, legs/whole body fat ratio, and (upper limbs+legs)/trunk fat ratio (P < 0.05), while there were no significant differences in the above body fat ratios and fat distribution indicators between the CPP and PPP groups (P > 0.05). For the girls with precocious puberty, the high body fat ratio group had significantly higher luteinizing hormone (LH) base value, luteinizing hormone releasing hormone (LHRH)-stimulated LH peak value, and LH/follicle-stimulating hormone peak value than the low body fat ratio group (P < 0.05). Compared with the control group, both the high body fat ratio and low body fat ratio groups had a significantly higher LH base value (P < 0.05). Conclusions The increase in body fat may be a factor inducing precocious puberty in girls, but further studies are needed to determine the mechanism.
- Subjects
PRECOCIOUS puberty; LUTEINIZING hormone releasing hormone; FAT; BODY mass index; DUAL-energy X-ray absorptiometry; ARM
- Publication
Chinese Journal of Contemporary Pediatrics, 2020, Vol 22, Issue 7, p762
- ISSN
1008-8830
- Publication type
Article
- DOI
10.7499/j.issn.1008-8830.1912076