We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Vasomodulatory effects of semi-purified fractions of garlic aqueous extract on chick chorioallantoic membrane.
- Authors
Hadriche-Jarraya, Heyfa; Limam, Ferid; Aouani, Ezzedine; Amri, Mohamed; Mokni, Meherzia
- Abstract
Allium sativum (As), commonly known as garlic, has been used for a long time, for its therapeutic effects. Recent studies showed the ability of As to modulate vascular activity. The present study aimed to investigate the vasomodulatory effects of aqueous extract of As and to analyse the molecular nature of the active components. Experiments were performed on chick chorioallantoic membrane. Fractions of garlic were directly injected using micropipette on a high vessel density area. Our results clearly indicated that garlic increased permeability and induced vasodilatation of blood vessels and capillaries. These effects were dose-dependent and had been observed just few minutes after the onset of treatment. The active component responsible of these effects, which had a low molecular weight seems to be of peptide nature and appeared different from Dially Sulfide (DAS) and Dially Disulfide (DADS).
- Subjects
CHORIOALLANTOIS; GARLIC; MOLECULAR weights; BLOOD vessels; TREATMENT effectiveness
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2021, Vol 34, Issue 3, p943
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2021.34.3.REG.943-949.1