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- Title
Acetate-induced myocardial depression during hemodialysis for acute renal failure.
- Authors
Vincent, Jean-Louis; Vanherweghem, Jean-Louis; Degaute, Jean-Paul; Berré, Jacques; Dufaye, Philippe; Kahn, Robert J.
- Abstract
We studied the cardiovascular effects of hemodialysis in five critically ill patients with ultrafiltration using, alternately, bicarbonate and acetate in the dialysate. After 3 hr of dialysis with acetate, significant decreases in both arterial pressure and stroke volume resulted in lowered left ventricular stroke work (P < 0.025). This effect persisted 30 min after the end of the dialysis (P < 0.025). Differences in the patients' cardiac preload were ruled out by similar pulmonary artery balloon-occluded pressures during both types of dialysis. These observations suggest that dialysis with acetate can result in myocardial depression. The use of bicarbonate dialysate is thus advisable for acute hemodialysis in critically ill patients.
- Subjects
ACUTE kidney failure; KIDNEY diseases; HEMODIALYSIS patients; CRITICALLY ill; MYOCARDIUM
- Publication
Kidney International, 1982, Vol 22, Issue 6, p653
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1982.225