We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Acute hypercalcemic hypertension in man: Role of hemodynamics, catecholamines, and renin.
- Authors
Marone, Claudio; Beretta-Piccoli, Carlo; Weidmann, Peter
- Abstract
The effect of acute hypercalcemia on blood pressure, blood volume, hemodynamic parameters, plasma norepinephrine, epinephrine, dopamine, renin, and aldosterone concentrations was investigated. After 1 hour of equilibration, 10 patients received an infusion of calcium gluconate in 5% dextrose (calcium 15 mg/kg of body wt in 3 hours). The calcium infusion increased the mean serum calcium from 8.7 to 13.0 mg/dl, the systolic blood pressure from 144 ± 10 to 184 ± (SEM) 12 mm Hg (P < 0.001), the diastolic pressure from 78 ± 4 to 93 ± 5 mm Hg (P < 0.01). The plasma volume was decreased by 9% (P < 0.001), whereas the hematocrit was increased (P < 0.05). Heart rate and cardiac output remained unchanged. Total peripheral resistance was increased from 1643 ± 223 to 2256 ± 387 dyne·sec/cms (P < 0.05). The plasma epinephrine concentration rose from 4.5 ± 0.7 to 6.9 ± 1.2 ng/dl (P < 0.01). The plasma norepinephrine concentration was unchanged after 2 hours and increased only slightly after 3 hours of calcium infusion. Plasma reran, aldosterone, and dopamine concentrations were not significantly changed. These findings demonstrate that acute hyper-calcemic hypertension is mediated by an increase in peripheral vascular resistance. Hypercalcemic hypertension may be induced by a direct effect of calcium on blood vessels: calcium-mediated increase in adrenal epinephrine release may play a mild contributory role, and plasma volume contraction, an inhibitory role.
- Subjects
HYPERTENSION; BLOOD circulation disorders; HEMODYNAMICS; BLOOD circulation; CATECHOLAMINES; AMINES; RENIN
- Publication
Kidney International, 1981, Vol 20, Issue 1, p92
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1981.109