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- Title
Quantifying risk over the life course - latency, age-related susceptibility, and other time-varying exposure metrics.
- Authors
Wang, Molin; Liao, Xiaomei; Laden, Francine; Spiegelman, Donna
- Abstract
Identification of the latency period and age-related susceptibility, if any, is an important aspect of assessing risks of environmental, nutritional, and occupational exposures. We consider estimation and inference for latency and age-related susceptibility in relative risk and excess risk models. We focus on likelihood-based methods for point and interval estimation of the latency period and age-related windows of susceptibility coupled with several commonly considered exposure metrics. The method is illustrated in a study of the timing of the effects of constituents of air pollution on mortality in the Nurses' Health Study. Copyright © 2016 John Wiley & Sons, Ltd.
- Subjects
AGE distribution; AGING; AIR pollution; DISEASE susceptibility; MORTALITY; PROBABILITY theory; RISK assessment; TIME; ENVIRONMENTAL exposure; STATISTICAL models
- Publication
Statistics in Medicine, 2016, Vol 35, Issue 13, p2283
- ISSN
0277-6715
- Publication type
journal article
- DOI
10.1002/sim.6864