We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
An investigation of the nature of induced suppression to experimental autoimmune thyroiditis.
- Authors
Parish, N. M.; Rayner, D.; Cooke, A.; Roitt, I. M.
- Abstract
When mice are pretreated with soluble mouse thyroglobulin (MTg), subsequent induction of autoantibodies in experimental allergic thyroiditis (EAT) is suppressed. This suppression can be reproducibly transferred to low-level irradiated syngeneic recipients and is specific for MTg. Injection of normal cells does not reverse this tolerance, also indicative of an active suppression. Neither can the induced unresponsiveness be overcome by immunization with cross-reactive xenogeneic Tg; although antibodies arc formed which will bind to MTg, these are not to epitopes to which antibodies are normally formed on immunization or towards which tolerance is induced. This implies that tolerance might be induced at least at the B-cell level, a view supported by the inability of DNP to provide a new carrier to break tolerance when conjugated to MTg. The poorer response to DNP in these animals also suggests anergy of the MTg-specific T helpers.
- Subjects
THYROGLOBULIN; LABORATORY mice; AUTOANTIBODIES; THYROID gland; IMMUNOGLOBULINS; IMMUNIZATION; ANTIGENS
- Publication
Immunology, 1988, Vol 63, Issue 2, p199
- ISSN
0019-2805
- Publication type
Article