We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Rapid Eye Movement Sleep Sawtooth Waves Are Associated with Widespread Cortical Activations.
- Authors
Frauscher, Birgit; von Ellenrieder, Nicolás; Dolezalova, Irena; Bouhadoun, Sarah; Gotman, Jean; Peter-Derex, Laure
- Abstract
Sawtooth waves (STW) are bursts of frontocentral slow oscillations recorded in the scalp electroencephalogram (EEG) during rapid eye movement (REM) sleep. Little is known about their cortical generators and functional significance. Stereo-EEG performed for presurgical epilepsy evaluation offers the unique possibility to study neurophysiology in situ in the human brain. We investigated intracranial correlates of scalp-detected STW in 26 patients (14 women) undergoing combined stereo-EEG/polysomnography. We visually marked STW segments in scalp EEG and selected stereo-EEG channels exhibiting normal activity for intracranial analyses. Channels were grouped in 30 brain regions. The spectral power in each channel and frequency band was computed during STW and non-STW control segments. Ripples (80-250 Hz) were automatically detected during STW and control segments. The spectral power in the different frequency bands and the ripple rates were then compared between STW and control segments in each brain region. An increase in 2-4 Hz power during STW segments was found in all brain regions, except the occipital lobe, with large effect sizes in the parietotemporal junction, the lateral and orbital frontal cortex, the anterior insula, and mesiotemporal structures. A widespread increase in high-frequency activity, including ripples, was observed concomitantly, involving the sensorimotor cortex, associative areas, and limbic structures. This distribution showed a high spatiotemporal heterogeneity. Our results suggest that STW are associated with widely distributed, but locally regulated REM sleep slow oscillations. By driving fast activities, STW may orchestrate synchronized reactivations of multifocal activities, allowing tagging of complex representations necessary for REM sleep-dependent memory consolidation.
- Subjects
RAPID eye movement sleep; HIGH-frequency ventilation (Therapy); SENSORIMOTOR cortex; OCCIPITAL lobe; BRAIN-computer interfaces; EYE movements
- Publication
Journal of Neuroscience, 2020, Vol 40, Issue 46, p8900
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.1586-20.2020