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- Title
Robust enumeration of cell subsets from tissue expression profiles.
- Authors
Newman, Aaron M; Liu, Chih Long; Green, Michael R; Gentles, Andrew J; Feng, Weiguo; Xu, Yue; Hoang, Chuong D; Diehn, Maximilian; Alizadeh, Ash A
- Abstract
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with respect to noise, unknown mixture content and closely related cell types. CIBERSORT should enable large-scale analysis of RNA mixtures for cellular biomarkers and therapeutic targets (http://cibersort.stanford.edu/).
- Subjects
GENE expression; COMBINATORIAL enumeration problems; RNA; TISSUE engineering; BIOMARKERS
- Publication
Nature Methods, 2015, Vol 12, Issue 5, p453
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.3337