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- Title
Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna.
- Authors
Li Hao; Li Rui-Xin; Han Biao; Zhao Bin; Hao Bao-Hui; Liu Ying-Jie; Zhang Xi-Zheng; Hao, Li; Rui-Xin, Li; Biao, Han; Bin, Zhao; Bao-Hui, Hao; Ying-Jie, Liu; Xi-Zheng, Zhang
- Abstract
<bold>Background: </bold>Fatigue damage of the long bones is prevalent in running athletes and military recruits due to vigorous mid- and long-term physical activity. The current study attempted to know the features of bony athletic fatigue damage and to explore the mechanism of fatigue damage repair through bone targeted remodeling process.<bold>Methods: </bold>Right ulnae of the Wistar rats were fatigue loaded on an INSTRON 5865 to construct the athletic fatigue damage model, and several time points (i.e. experimental days: 0, 7, 13 and 19) were selected to simulate physiological status, preliminary, mid-term and perennial stage during continuous high-intensive training, respectively. The multi-level responses of rat ulnae under the athletic fatigue loading, including cellular protein expression, micro damage or micro-crack and macro mechanical properties, were tested and statistically analyzed.<bold>Results: </bold>Wistar rats, subjected to the athletic fatigue loading protocol, experienced a decrease of ulna fatigue mechanical properties and an active bone resorption of the loaded ulnae in the early stage, whereafter, a hyperactive bone formation and significant improvements of ulnae fatigue mechanical properties were detected. However, a deterioration of quasi-static mechanical properties in the subsequent period implied limitations of bone remodeling to maintain the bearing capacity of bone during long-term strenuous exercise.<bold>Conclusions: </bold>In summary, after athletic fatigue loading, bone targeted remodeling is activated and proceeds to repair fatigue damage, but only to a certain extent.
- Subjects
SPORTS injuries; PROTEIN expression; DISEASE prevalence; LABORATORY rats; FATIGUE (Physiology); PHYSIOLOGY; ULNA; BONE remodeling; ANIMAL experimentation; KINEMATICS; RATS; SPORTS; PHYSIOLOGIC strain
- Publication
BioMedical Engineering OnLine, 2017, Vol 16, p1
- ISSN
1475-925X
- Publication type
journal article
- DOI
10.1186/s12938-017-0384-1