We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Extensive myelitis associated with anti-NMDA receptor antibodies.
- Authors
Outteryck, Olivier; Baille, Guillaume; Hodel, Jérôme; Giroux, Marianne; Lacour, Arnaud; Honnorat, Jérôme; Zéphir, Hélène; Vermersch, Patrick
- Abstract
<bold>Background: </bold>Encephalitis with anti-N-methyl-D-aspartate receptor antibodies (anti-NMDAR-Ab) is a rapid-onset encephalitis including psychosis, seizures, various movement disorders and autonomic system disturbances.<bold>Case Presentation: </bold>We report a very unusual case of extensive myelitis associated with anti-NMDAR-Ab. MRI also revealed a hyperintense T2 lesion, non-suggestive of MS, which progressively extended, associated with periventricular gadolinium enhancement visualized on brain MRI. Ophthalmological evaluation showed subclinical right optic neuritis. The absence of anti-AQP4 antibody argued against neuromyelitis optica spectrum disorder. A slight psychomotor slowing prompted us to search for various causes of autoimmune encephalitis. Anti-NMDAR-Ab was found in cerebrospinal fluid.<bold>Conclusion: </bold>In patients with extensive myelitis who are seronegative for anti-AQP4 antibodies, and after other classical causes have been excluded, the hypothesis of atypical anti-NMDAR-Ab encephalitis should also be considered.
- Publication
BMC Neurology, 2013, Vol 13, Issue 1, p211
- ISSN
1471-2377
- Publication type
journal article
- DOI
10.1186/1471-2377-13-211