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- Title
A ratiometric fluorescent sensor for the mitochondrial copper pool.
- Authors
Shen, Clara; Kolanowski, Jacek L.; Tran, Carmen M.-N.; Kaur, Amandeep; Akerfeldt, Mia C.; Rahme, Matthew S.; Hambley, Trevor W.; New, Elizabeth J.
- Abstract
Copper plays a key role in the modulation of cellular function, defence, and growth. Here we present InCCu1, a ratiometric fluorescent sensor for mitochondrial copper, which changes from red to blue emission in the presence of Cu(i). Employing this probe in microscopy and flow cytometry, we show that cisplatin-treated cells have an impaired ability to accumulate copper in the mitochondria.
- Publication
Metallomics, 2016, Vol 8, Issue 9, p915
- ISSN
1756-5901
- Publication type
Article
- DOI
10.1039/c6mt00083e