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- Title
HIV and T follicular helper cells: a dangerous relationship.
- Authors
Vinuesa, Carola G.
- Abstract
HIV infection leads to progressive destruction of infected CD4 T cells, hypergammaglobulinemia, and loss of memory B cells. Germinal centers, which are key to memory B cell formation and protective antibody responses, are major HIV reservoirs in which the virus replicates within T follicular helper (TFH) cells. In this issue of the JCI, the Koup and Streeck groups report that chronic SIV/HIV infection promotes TFH cell accumulation, which may drive B cell dysregulation. Their discoveries suggest that HIV harnesses TFH cells to evade the antibody response.
- Subjects
T helper cells; HIV infections; B cells; CD4 antigen; IMMUNOGLOBULINS; HYPERGAMMAGLOBULINEMIA
- Publication
Journal of Clinical Investigation, 2012, Vol 122, Issue 9, p3059
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI65175