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- Title
Lack of everolimus diffusion in pleural fluid during pleural progression of breast cancer: A case report.
- Authors
Vaury, Célia; Macaire, Pauline; Goirand, Françoise; Coudert, Bruno; Guérard, Pascal; Schmitt, Antonin
- Abstract
Background: We report here a case where no everolimus pleural diffusion was evidenced at the same time of pleural progression of a metastatic breast cancer treated with everolimus and exemestane. Case description: A 69-year-old woman was diagnosed in October 2006 with stage III invasive ductal breast adenocarcinoma. After nine months of everolimus and exemestane treatment, she presented with a pleural progression. Everolimus concentration was measured in blood and in pleural fluid. Residual blood concentration was at 9.1 ng/mL, while no everolimus was observed in the pleural fluid. Management and outcome: Due to inefficacy of everolimus in this patient, she was switched to palbociclib and fulvestrant. Conclusion: Everolimus seems to have a poor diffusion in the pleural fluid.
- Subjects
BREAST tumors; PLEURAL effusions; PROTEIN-tyrosine kinase inhibitors; DISEASE progression; EXEMESTANE; EVEROLIMUS
- Publication
Journal of Oncology Pharmacy Practice, 2021, Vol 27, Issue 1, p235
- ISSN
1078-1552
- Publication type
Article
- DOI
10.1177/1078155220927771