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- Title
Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation.
- Authors
Yan, Shian‐Jang; Zartman, Jeremiah J; Zhang, Minjie; Scott, Anthony; Shvartsman, Stanislav Y; Li, Willis X
- Abstract
Cell differentiation in developing tissues is controlled by a small set of signaling pathways, which must coordinate the timing and levels of activation to ensure robust and precise outcomes. Highly coordinated activation of signaling pathways can result from cross-regulatory interactions in multi-pathway networks. Here we explore the dynamics and function of pathway coordination between the EGFR and DPP pathways during Drosophila wing-vein differentiation. We show that simultaneous activation of both the EGFR and DPP pathways must be maintained for vein cell differentiation and that above-threshold ectopic activation of either pathway is sufficient to drive vein cell differentiation outside the proveins. The joint activation of the EGFR and DPP signaling systems is ensured by a positive feedback loop, in which the two pathways stimulate each other at the level of ligand production.
- Subjects
CELL differentiation; TISSUES; DROSOPHILA; VEINS; LIGANDS (Biochemistry)
- Publication
Molecular Systems Biology, 2009, Vol 5, Issue 1, p278
- ISSN
1744-4292
- Publication type
Article
- DOI
10.1038/msb.2009.35