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- Title
Mild and Soft Catalyzed Trifluoromethylthiolation of Boronic Acids: The Crucial Role of Water.
- Authors
Glenadel, Quentin; Alazet, Sébastien; Tlili, Anis; Billard, Thierry
- Abstract
The most reactive 2nd generation of trifluoromethanesulfenamides undergoes a copper-catalyzed cross-coupling reaction with boronic acids to afford CF3S-molecules. Contrary to the previous methods in the literature, no base addition, no heating, and no large excess of reagents are required to obtain good results. Furthermore, a crucial role of a small amount of water to favor this reaction has been demonstrated. This constitutes the mildest described conditions for such a reaction.
- Subjects
BORONIC acids; NONCARBOXYLIC acids; ORGANOBORON compounds; ACIDOLYSIS; CATALYSIS
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 42, p14694
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201502338