We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesen in der Isochinolinreihe Synthesen von 7-Hydroxy -6-methoxy-2-methyl- 1-(4-hydroxy-3, 5-dimethoxy-phenäthyl)-1, 2, 3, 4-tetrahydro-isochinolin, einem wichtigen Zwischenprodukt zur Synthese von Homoapomorphin-Alkaloiden.
- Authors
Brossi, A.; Van Burik, J.; Teitel, S.
- Abstract
Polymethoxylated 1-phenethyl-3, 4-dihydro- and -1, 2, 3, 4-tetrahydro-isoquinolines were selectively demethylated by varying the mineral acid treatment. Under these conditions, the 6-methoxyl was the most stable, while the 4′-methoxyl was the most labile. Based on this study and by employing an unprotected phenolic intermediate in the Bischler-Napieralski cyclization, an efficient, simple and technically feasible synthesis of the diphenol 1, an important intermediate in the synthesis of homoapomorphine alkaloids, was achieved.
- Publication
Helvetica Chimica Acta, 1968, Vol 51, Issue 8, p1965
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19680510816