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- Title
The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries.
- Authors
Balis, Peter; Berenyiova, Andrea; Misak, Anton; Grman, Marian; Rostakova, Zuzana; Waczulikova, Iveta; Cacanyiova, Sona; Domínguez-Álvarez, Enrique; Ondrias, Karol
- Abstract
Phthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive selenium species including H2Se. It is a potential compound for Se supplementation which exerts several biological effects, but its effect on the cardiovascular system is still unknown. Therefore, herein we aimed to study how R-Se affects rat hemodynamic parameters and vasoactive properties in isolated arteries. The right jugular vein of anesthetized Wistar male rats was cannulated for IV administration of R-Se. The arterial pulse waveform (APW) was detected by cannulation of the left carotid artery, enabling the evaluation of 35 parameters. R-Se (1–2 µmol kg−1), but not phthalic anhydride or phthalic thioanhydride, transiently modulated most of the APW parameters including a decrease in systolic and diastolic blood pressure, heart rate, dP/dtmax relative level, or anacrotic/dicrotic notches, whereas systolic area, dP/dtmin delay, dP/dtd delay, anacrotic notch relative level or its delay increased. R-Se (~10–100 µmol L−1) significantly decreased the tension of precontracted mesenteric, femoral, and renal arteries, whereas it showed a moderate vasorelaxation effect on thoracic aorta isolated from normotensive Wistar rats. The results imply that R-Se acts on vascular smooth muscle cells, which might underlie the effects of R-Se on the rat hemodynamic parameters.
- Subjects
BLOOD pressure; RENAL artery; FEMORAL artery; VASCULAR smooth muscle; DIASTOLIC blood pressure; CARDIOVASCULAR system
- Publication
Molecules, 2023, Vol 28, Issue 12, p4826
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28124826