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- Title
Tobacco smoking impairs the local immunosurveillance in the uterine cervix. An immunohistochemical study.
- Authors
Poppe, Willy A.J.; Ide, Paul S.; Drijkoningen, Maria P.G.; Lauweryns, Joseph M.; van Assche, Andre; Poppe, W A; Ide, P S; Drijkoningen, M P; Lauweryns, J M; Van Assche, F A
- Abstract
Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cervix. This suggests a local impairment of cell-mediated immunity by smoking. This immunosuppressive effect could support the concept that smoking is an independent risk factor for cervical neoplasia.
- Subjects
CELLULAR immunity; CERVIX uteri; EPITHELIAL cells; SMOKING; T cells; HLA-B27 antigen; CYTOMETRY; CASE-control method
- Publication
Gynecologic & Obstetric Investigation, 1995, Vol 39, Issue 1, p34
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000292372