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- Title
Mutations of mitotic checkpoint genes in human cancers.
- Authors
Cahill, Daniel P.; Lengauer, Christoph; Yu, Jian; Riggins, Gregory J.; Willson, James K. V.; Markowitz, Sanford D.; Kinzler, Kenneth W.; Vogelstein, Bert
- Abstract
Presents research which showed that chromosomal instability (CIN) is consistently associated with the loss of function of a mitotic checkpoint in human cancers. Genetic instability and neoplasia in two different forms; CIN and aneuploidy; Impact of loss of mitotic checkpoint; Role of BUB1 gene; How normal mitotic checkpoints become defective.
- Subjects
CHROMOSOME abnormalities; MITOSIS; ANEUPLOIDY; CANCER genetics
- Publication
Nature, 1998, Vol 392, Issue 6673, p300
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/32688