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- Title
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD.
- Authors
Enari, Masato; Sakahira, Hideki; Yokoyama, Hideki; Okawa, Katsuya; Iwamatsu, Akihiro; Nagata, Shigekazu
- Abstract
Presents research which identified a caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD) in the cytoplasmic fraction of mouse lymphoma cells. Regulation of homeostasis of animals through apoptosis; Genetic mediation of apoptosis through caspase family of proteases; Degradation of chromosomal DNA; Interactions between CAD and ICAD in apoptosis.
- Subjects
APOPTOSIS; DEOXYRIBONUCLEASES; CYTOPLASM; GENETICS
- Publication
Nature, 1998, Vol 391, Issue 6662, p43
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/34112