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- Title
Key network approach reveals new insight into Alzheimer's disease.
- Authors
Schluesener, Jan K.; Xiaomei Zhu; Schluesener, Hermann J.; Gao-Wei Wang; Ping Ao
- Abstract
Alzheimer's disease (AD) is a severe neurodegenerative disorder without curative treatment. Extensive data on pathological molecular processes have been accumulated over the last years. These data combined allows a systems biology approach to identify key regulatory elements of AD and to establish a model descriptive of the disease process which can be used for the development of therapeutic agents. In this study, the authors propose a closed network that uses a set of nodes (amyloid beta, tau, beta-secretase, glutamate, cyclin-dependent kinase 5, phosphoinositide 3-kinase and hypoxia-induced factor 1 alpha) as key elements of importance to the pathogenesis of AD. The proposed network, in total 39 nodes, is able to become a novel tool capable of providing new insights into AD, such as feedback loops. Further, it highlights interconnections between pathways and identifies their combination for therapy of AD.
- Subjects
ALZHEIMER'S disease; CLINICAL trials; PATHOLOGY; THERAPEUTICS; AMYLOID
- Publication
IET Systems Biology (Wiley-Blackwell), 2014, Vol 8, Issue 4, p169
- ISSN
1751-8849
- Publication type
Article
- DOI
10.1049/iet-syb.2013.0047