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- Title
Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells.
- Authors
Li, Li; Wan, Zhongjun; Wang, Ruxiang; Zhao, Yuxin; Ye, Yida; Yang, Pengcheng; Qi, Yan; Jiang, Wei; Cai, Lin; Zhang, Donghui
- Abstract
In addition, although no significant difference in sarcomere structure was observed between EPSC-CMs and iPSC-CMs, the EPSC-CM-derived engineered heart tissue (EHT) (Fig. These authors contributed equally: Li Li, Zhongjun Wan Dear Editor, The availability of functional human cardiomyocytes is essential for cardiac disease modeling, drug screening, and cell therapy, whereas donor human cardiomyocytes are incredibly scarce. However, whether EPSCs can efficiently generate other lineages such as cardiomyocytes and how the EPSC-derived cardiomyocytes (EPSC-CMs) function compared with ESC/iPSC-CMs have not been studied yet.
- Subjects
PLURIPOTENT stem cells; HUMAN embryonic stem cells
- Publication
Cell Discovery, 2022, Vol 8, Issue 1, p1
- ISSN
2056-5968
- Publication type
Article
- DOI
10.1038/s41421-022-00446-7