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- Title
Histological evidences suggest recommending orchiopexy within the first year of life for children with unilateral inguinal cryptorchid testis.
- Authors
Kwan Hyun Park; Joo Hwan Lee; Jae Joon Han; Sang Don Lee; Sang Yong Song
- Abstract
Objective: To determine the optimal timing for orchiopexy, we evaluated the histological parameters of the cryptorchid testis. Methods: We prospectively performed testicular biopsy in a total of 65 consecutive children with palpable unilateral inguinal cryptorchid testes. For controls, we used testicular histological slides from 15 age-matched children with testicular tumor. To investigate the fertility potential, we analyzed the parameters including mean tubular diameter (MTD), mean tubular fertility index (MTFI), germ cell count/tubule (GCC), Sertoli cell index (SCI) and interstitial fibrosis index (IFI). Results: The MTFI and GCC in children ≤1 years of age were significantly higher than those of other older age groups. The MTFI, GCC and IFI were significantly better in patients ≤2 years of age when compared to those of > 2 years. Compared to the controls, the MTFI and GCC in the patients were significantly worse in those aged > 2 years at surgical repair. In the ≤2-year age group, the MTFI and GCC of the cryptorchid testis showed a decreasing tendency with age, which were contrasting with the ascending curves in the control and the curves crossed at 1–2 years of age in each parameter. Conclusions: To protect fertility potential, we recommend, orchiopexy should be performed within the first year of life, and no later than 2 years of age in patients with palpable inguinal cryptorchid testes.
- Subjects
ORCHIOPEXY; CRYPTORCHISM; TESTIS surgery; TESTIS; MALE reproductive organs; OLDER men; HUMAN fertility; THERAPEUTICS
- Publication
International Journal of Urology, 2007, Vol 14, Issue 7, p616
- ISSN
0919-8172
- Publication type
Article
- DOI
10.1111/j.1442-2042.2007.01788.x