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- Title
Skin colonization with beta papilloma virus drives tissue immunity and resistance to squamous cell cancer.
- Authors
Hochheiser, Katharina; Gyorki, David E; Gebhardt, Thomas
- Abstract
At the same time, T SB RM sb cells may recognize a broad array of stress molecules which are likely to be expressed at elevated levels by virus-infected SCC cells, including the NKG2D ligands MICA (human) and Rae-1 (mouse). Therefore, T SB RM sb cell-mediated protection may at least in part be a result of direct recognition of virus-infected cancer cells, explaining the apparent selection of virus-negative escape variants during eventual SCC development.
- Subjects
SQUAMOUS cell carcinoma; PAPILLOMAVIRUSES; KERATINOCYTES; IMMUNITY; SKIN; COLONIZATION; CELL transformation; EPIDERMIS
- Publication
Immunology & Cell Biology, 2020, Vol 98, Issue 1, p9
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1111/imcb.12302