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- Title
Colonic mucosal lesions associated with long-term or short-term administration of nonsteroidal anti-inflammatory drugs.
- Authors
Shibuya, Tomoyoshi; Ohkusa, Toshifumi; Yokoyama, Tetsuji; Harada, Akira; Beppu, Kazuko; Sakamoto, Naoto; Osada, Taro; Nagahara, Akihito; Terai, Takeshi; Otaka, Michiro; Ogihara, Tatsuo; Watanabe, Sumio
- Abstract
Aim The effects of short- or long-term administration of nonsteroidal anti-inflammatory drugs (NSAIDs) on the colon have not been well characterized. We assessed the risk of developing colonic mucosal lesions according to the duration of exposure to NSAIDs: short-term and/or long-term use. Method A case-controlled study was performed by reviewing medical records for endoscopic findings, underlying disease, pre-endoscopic symptoms, category of NSAIDs used and duration of use. The patients underwent colonoscopy between January and October 2004, and 75 colitis cases and 1801 non-colitis controls were identified. The prevalence of NSAID use was compared between the cases and controls. The age- and sex- adjusted odds ratios (OR) were estimated using multiple logistic regression models. Results NSAIDs had been used in colitis cases and non-colitis controls for over six months in 20.0% and 12.7%, and for one week in 4.0% and 2.1%. Overall 76.0% and 85.2% had not received NSAIDs. The adjusted OR (95% confidence interval) for colonic mucosal lesions with short- and long term NSAID administration combined vs. non-use was 2.04 (1.16-3.61). When determined separately for short- and long-term NSAID users, the adjusted ORs were 1.48 (0.42-5.25) and 2.21 (1.19-4.11), compared to non-users. These values signify a trend toward an increased frequency of colonic mucosal lesions with longer use of NSAIDs ( P=0.011 for trend). Conclusion Long-term use of NSAIDs increased the risk of colonic mucosal lesions, suggesting that NSAIDs may contribute to the pathogenesis of colonic ulcer or colitis.
- Subjects
NONSTEROIDAL anti-inflammatory agents; DISEASE prevalence; COLONOSCOPY; COLON diseases; PRECANCEROUS conditions
- Publication
Colorectal Disease, 2010, Vol 12, Issue 11, p1113
- ISSN
1462-8910
- Publication type
Article
- DOI
10.1111/j.1463-1318.2009.01948.x