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- Title
Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) System.
- Authors
Tan, Li; Li, Si Rui; Jiang, Bei; Hu, Xiao Mei; Li, Shu
- Abstract
Staphylococcus aureus can cause numerous different diseases, which has been attributed to its large repertoire of virulence factors, many of which are under the control of the accessory gene regulator (agr) quorum sensing system. Under conditions of high cell density, agr increases the production of many virulence factors, decreases expression of several colonization factors, and is intimately associated with the pathogenesis and biofilm formation of S. aureus. This review summarizes our current understanding of the molecular mechanisms underlying agr quorum sensing and the regulation of agr expression. The discussion also examines subgroups of agr and their association with different diseases, and concludes with an analysis of strategies for designing drugs and vaccines that target agr to combat S. aureus infections.
- Subjects
GENE regulatory networks; GENETICS of staphylococcus aureus infections; VIRULENCE of bacteria
- Publication
Frontiers in Microbiology, 2018, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2018.00055