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- Title
Decreased density of CD3+ tumor-infiltrating lymphocytes during gastric cancer progression.
- Authors
Arigami, Takaaki; Uenosono, Yoshikazu; Ishigami, Sumiya; Matsushita, Daisuke; Hirahara, Tetsushi; Yanagita, Shigehiro; Okumura, Hiroshi; Uchikado, Yasuto; Nakajo, Akihiro; Kijima, Yuko; Natsugoe, Shoji
- Abstract
Background and Aim Tumor cells escape host immunosurveillance and thus produce an advantageous environment for tumor progression. Recent studies have demonstrated that tumor-infiltrating lymphocytes ( TILs) play a principal role in the immune response to tumors. However, little is understood about numerical alterations in CD3+ TILs during tumor progression in patients with gastric cancer. The present study examines the density of CD3+ TILs to elucidate their clinical significance in gastric cancer. Methods The numbers of CD3+ TILs in 120 resected specimens from patients with gastric cancer and 27 endoscopic resected specimens from patients with gastric adenoma were immunohistochemically assessed using a CD3 polyclonal antibody. Results The mean number of CD3+ TILs (± SD) in the patients with gastric cancer and adenoma was 87.5 ± 59.8 and 379.6 ± 128.1, respectively. Significantly more CD3+ TILs were found in specimens from patients with gastric adenoma than with gastric cancer ( P < 0.0001). The numbers of CD3+ TILs significantly correlated with depth of tumor invasion, lymph node metastasis, and stage ( P = 0.022, P = 0.0004, and P = 0.011, respectively). The 5-year survival rate was significantly poorer for patients with fewer CD3+ TILs ( P = 0.004). Multivariate analysis selected the density of CD3+ TILs as an independent prognostic factor ( P = 0.034). Conclusions Our results demonstrated that the density of CD3+ TILs decreases during tumor progression. The density of CD3+ TILs is an immunological predictor of lymph node metastasis and disease outcome in patients with gastric cancer.
- Subjects
LYMPHOCYTES; LEUCOCYTES; CARCINOGENS; ONCOLOGY; DENSITOMETERS
- Publication
Journal of Gastroenterology & Hepatology, 2014, Vol 29, Issue 7, p1435
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/jgh.12551