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- Title
Serum Helicobacter pylori Cag A antibody titer as a useful marker for advanced inflammation in the stomach in Japan.
- Authors
Shiota, Seiji; Murakami, Kazunari; Okimoto, Tadayoshi; Kodama, Masaaki; Yamaoka, Yoshio
- Abstract
Background and Aim Subjects infected with Helicobacter pylori containing cagA do not always induce serum Cag A antibody. Our previous meta-analysis showed that serum Cag A seropositivity was associated with gastric cancer even in East Asian countries. However, it remains unclear why serum Cag A-positive status is associated with gastric cancer. In this study, we aimed to examine the relationship between anti- Cag A antibody titer and the levels of pepsinogen ( PG), and histological score. Methods Eighty-eight H. pylori-positive Japanese patients with gastritis were included. Serum Cag A antibody titer, PG I, and PG II were evaluated by ELISA. Histological scores were evaluated according to Update Sydney System. Cag A expression was examined by immunoblot. Results Seroprevalence of Cag A antibody was found in 75.0%. Interestingly, serum Cag A antibody titer was significantly correlated with PG I and PG II levels ( P = 0.003 and 0.004, respectively). Serum Cag A antibody titer was also significantly correlated with mucosal inflammation in the corpus ( P = 0.04). On the other hand, bacterial density was not related with Cag A antibody titer. Cag A expression level of the strains was irrespective of the status of PG and serum Cag A antibody. Conclusions Subjects with higher serum Cag A antibody titer can be considered as high-risk population for the development of gastric cancer from the point of strong gastric inflammatory response even in Japan. Host recognition rather than bacterial colonization might be associated with the difference of serum Cag A antibody titer.
- Subjects
JAPAN; HELICOBACTER pylori; ANTIBODY titer; PEPSINOGEN; INFLAMMATION; STOMACH; SERUM; IMMUNOGLOBULINS
- Publication
Journal of Gastroenterology & Hepatology, 2014, Vol 29, Issue 1, p67
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/jgh.12359