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- Title
Comparison of ovarian cancer patients and people with familial history of ovary/breast cancer for finding ovarian cancer risk factors.
- Authors
Youn Jin Choi; Seong Eun Bak; Min Yeop Whang; Soo Young Hur
- Abstract
Objective: Risk of developing ovarian cancer increases if there is a family history of ovarian cancer or breast cancer, and one of the causes is mutation in the BRCA1 or BRCA2 genes. Therefore, people with a family history of ovarian cancer or breast cancer may undergo BRCA1/2 genetic testing to prevent ovarian cancer, and if a mutation is discovered, they visit clinic more often than those who do not. However, there are many cases where ovarian cancer occurs even when gene mutations are not identified, we investigate to find factors that affect the development of ovarian cancer other than the BRCA1/2 genes. Methods: We reviewed anonymized data of ovarian cancer 2,176 patients and healthy 273 subjects from clinical data warehouse for finding ovarian cancer risk factor. Familial history, age at menarche, menopause status, pregnancy history, and BRCA1, BRCA2 mutations were also analyzed. Results: In univariate analysis, significant variables with p<0.05 were identified as factors such as number of family cancers(breast/ovary/pancreas), BRCA1 mutant and variants of uncertain significance (VUS), number of BRCA family cancers, pregnancy history, and body mass index 23 kg/m² or higher. When multivariate analysis was performed using the stepwise method, number of family cancers(breast/ovary/pancreas), BRCA1 mutant, and VUS were confirmed as meaningful results. Conclusion: Therefore, continuous follow-up will be necessary for the healthy people with not only for the number of family cancers but also for BRCA1/2 VUS.
- Subjects
OVARIAN cancer; BREAST cancer; DISEASE risk factors; CANCER patients; BRCA genes
- Publication
Journal of Gynecologic Oncology, 2024, Vol 35, p37
- ISSN
2005-0380
- Publication type
Article
- DOI
10.3802/jgo.2024.35.S2.P33