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- Title
Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP) and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP) for Uncomplicated falciparum Malaria in Equatorial Guinea (Central Africa).
- Authors
Charle, Pilar; Berzosa, Pedro; Descalzo, Miguel Angel; Lucio, Aida de; Raso, Jose; Obono, Jacqueline; Lwanga, Magdalena; Nlang, Natividad; Nchama, Araceli; Mangue, Catalina; Micha, Anastasio; Nsee, Natividad; Mesie, Rosario; Benito, Agustín; Roche2, Jesús
- Abstract
Objectives. The objectives of the study were (i) to evaluate the efficacy of combination drugs, such as artesunate + sulphadoxinepyrimethamine (AS + SP) and amodiaquine + sulphadoxine-pyripethamine (AQ+ SP) in treatment of uncomplicated falciparum malaria (ii) to differentiate recrudescence from reinfection by analysing msp-1 and msp-2 genes of Plasmodium falciparum in treatment failure cases. Methods. We carried out an in vivo study in the year 2005 in 206 children between 6 to 59 months age groups. Of the 206, 120 received AQ+ SP, and 86 received AS + SP. A clinical and parasitological followup during 14 days was undertaken. Finger-prick blood sample from each patient was taken onWhatman filter paper (no. 3) on days 0, 7, 14 and also the day when the parasite and symptoms reappeared for PCR analysis. Results. Late treatment failure was observed in 3.5% (4/114) with AQ+ SP, and 2.5% (2/79) with AS + SP. The success rate was 96.5% with AQ+ SP and 97.5% with AS + SP. No deaths and severe reactions were recorded. Out of the 6 treatment failure cases, one was reinfection as observed by PCR analysis of msp-1 and msp-2 genes on day 14. Discussion. Both the combinations found to be efficacious and safe and could be used as a first-line treatment for uncomplicated falciparum malaria in Equatorial Guinea.
- Subjects
EQUATORIAL Guinea; CENTRAL Africa; MALARIA; DRUG efficacy; PROTOZOAN diseases; CONTROLLED drugs; PLASMODIUM falciparum
- Publication
Journal of Tropical Medicine (16879686), 2009, p1
- ISSN
1687-9686
- Publication type
Article
- DOI
10.1155/2009/781865