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- Title
Histological transformation from non-small cell to small cell lung carcinoma after treatment with epidermal growth factor receptor-tyrosine kinase inhibitor.
- Authors
Kim, Woo‐Jin; Kim, Sunmin; Choi, Hayoung; Chang, Jinsun; Shin, Hong‐Joon; Park, Cheol‐Kyu; Oh, In‐Jae; Kim, Kyu‐Sik; Kim, Young‐Chul; Choi, Yoo‐Duk
- Abstract
Several cases of acquired resistance in patients with activating epidermal growth factor receptor ( EGFR) mutation have been reported. However, rare clinical cases exist of a transformation to small cell lung cancer ( SCLC) following treatment with EGFR-tyrosine kinase inhibitors ( TKIs). We report a case of non-small cell lung cancer ( NSCLC) with L858R mutation at the time of diagnosis. After failure of EGFR-TKI therapy, we performed additional histopathologic examinations. We confirmed that the patient had a histological transformation from NSCLC to SCLC. We performed chemotherapy with etoposide and cisplatin against the SCLC and radiologic findings were improved.
- Subjects
ANTINEOPLASTIC agents; CISPLATIN; ETOPOSIDE; METASTASIS; PROTEIN-tyrosine kinase inhibitors; SMALL cell carcinoma; BIOPSY; DIAGNOSTIC imaging; DRUG resistance; EPIDERMAL growth factor; LUNG cancer; GENETIC mutation; DIAGNOSIS; THERAPEUTICS
- Publication
Thoracic Cancer, 2015, Vol 6, Issue 6, p800
- ISSN
1759-7706
- Publication type
Article
- DOI
10.1111/1759-7714.12217