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- Title
Histopathological Features of Helicobacter pylori Infection in Gastric Mucosa.
- Authors
Wang, Yang-Kun; Li, Chun; Zhou, Yong-Mei; Zeng, Lei; Li, Ying-Ying; Huang, Si-Lin; Zhu, Chao-Ya; Wang, Yue; Wang, Su-Nan; Chen, Xiao-Dong
- Abstract
Discussion The present study found that patients with gastric mucosal Hp infection not only presented differences in terms of the abundance of the bacteria but also concerning the degree of gastric mucosal damage and the histopathological types of Hp infection in the gastric mucosa that developed into intraepithelial neoplasia. Since Hp infection is specific and selectively adheres to the cytoplasm of the surface epithelial cells, in patients with Hp infection developing into intraepithelial neoplasia, and, ultimately, gastric adenocarcinoma, the disappearance of the surface epithelial cells renders determining the cause of the infection in the gastric adenocarcinoma tissue problematic, which is also why Hp infection leads to a low rate of gastric cancer. The present study also revealed that intestinal metaplastic cells were not infected by Hp; conversely, following Hp infection, malignant transformation of the gastric glandular epithelial cells occurred, and the epithelial cells exhibited characteristic hazy basophilic changes in the cytoplasm and nucleus. If early control is provided, most cases of Hp infection in the gastric mucosa at the mucous layer infection stage, surface epithelial cell infection stage, and lamina propria lesion stage can be improved, with full recovery frequently achieved.
- Subjects
GASTRIC mucosa; HELICOBACTER pylori infections; PANCREATIC intraepithelial neoplasia; MUCOSA-associated lymphoid tissue lymphoma; HISTOPATHOLOGY
- Publication
Journal of Inflammation Research, 2022, Vol 15, p6231
- ISSN
1178-7031
- Publication type
Article
- DOI
10.2147/JIR.S383075