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- Title
Synthesis of Chiral α-Benzyl- β<sup>2</sup>-hydroxy Carboxylic Acids through Iridium-Catalyzed Asymmetric Hydrogenation of α-Oxymethylcinnamic Acids.
- Authors
Li, Ze-Yu; Song, Song; Zhu, Shou-Fei; Guo, Na; Wang, Li-Xin; Zhou, Qi-Lin
- Abstract
An asymmetric hydrogenation of α-oxymethylcinnamic acids was developed by using chiral spiro phosphine-oxazoline/iridium complexes as catalysts to prepare β2-hydroxycarboxylic acids with high reactivity (TON up to 2000) and excellent enantioselectivity (up to 99.5% ee). By using this highly efficient asymmetric hydrogenation as a key step, a concise total synthesis of natural product homoisoflavone ( S)-(+)- 4 was accomplished.
- Subjects
IRIDIUM catalysts; ASYMMETRIC synthesis; HYDROXY carboxylic acids; CATALYTIC hydrogenation; LIGANDS (Chemistry)
- Publication
Chinese Journal of Chemistry, 2014, Vol 32, Issue 8, p783
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.201400361