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- Title
Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis.
- Authors
Takahara, Masakazu; Ichikawa, Ryutaro; Oda, Yoshinao; Uchi, Hiroshi; Takeuchi, Satoshi; Moroi, Yoichi; Kiryu, Hiromaro; Furue, Masutaka
- Abstract
Desmoplastic fibroblastoma is a rare, benign, soft tissue tumor. We describe a case of superficial desmoplastic fibroblastoma presenting as a protruding nodule. A 41-year-old woman presented with a painless, firm, elevated nodule with ulceration on her left thigh. Histological examination from total excision showed a well-circumscribed tumor in the dermis, which comprised of spindle, oval and stellate cells arranged in a haphazard fashion, accompanied by abundant collagenous stroma and inconspicuous vasculature. Immunohistochemically, the tumor cells were positive for vimentin, and focally positive for α-smooth muscle actin and muscle-specific actin, but negative for CD34, S-100 protein, desmin and β-catenin. We diagnosed this case as desmoplastic fibroblastoma arising in the dermis and superficial subcutaneous tissue.
- Subjects
TUMORS; SKIN diseases; IMMUNOHISTOCHEMISTRY; ACTIN; CELLS
- Publication
Journal of Cutaneous Pathology, 2008, Vol 35, p70
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.2007.00964.x