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- Title
Orofacial findings in chronic granulomatousdisease: report of twelve patients and review ofthe literature.
- Authors
Dar-Odeh, Najla S.; Hayajneh, Wail A.; Abu-Hammad, Osama A.; Hammad, Huda M.; Al-Wahadneh, Adel M.; Bulos, Najwa K.; Mahafzah, Azmi M.; Shomaf, Maha S.; El-Maaytah, Mohammed A.; Bakri, Faris G.,1
- Abstract
Background: Chronic granulomatous disease is an extremely rare primary immunodeficiency syndrome that can be associated with various oral complications. This can affect high number of patients. However, data on oral complications is sparse. Here we will review the literature and describe the orofacial findings in 12 patients. Findings: The age range was 5-31 years. Oral findings were variable, and reflected a low level of oral hygiene. They included periodontitis, rampant caries, gingivitis, aphthous-like ulcers, and geographic tongue. One patient had white patches on the buccal mucosa similar to lichen planus. Another patient had a nodular dorsum of the tongue associated with fissured and geographic tongue. Biopsies from the latter two lesions revealed chronic nonspecific mucositis. Panoramic radiographs showed extensive periodontitis in one patient and periapical lesions in another patient. Conclusion: Patients with chronic granulomatous disease may develop oral lesions reflecting susceptibility to infections and inflammation. It is also possible that social and genetic factors may influence the development of this complication. Therefore, oral hygiene must be kept at an optimum level to prevent infections that can be difficult to manage.
- Subjects
CHRONIC granulomatous disease; GRANULOMA; LEUCOCYTE disorders; GINGIVITIS; INFLAMMATION; ORAL hygiene; MUCOUS membranes; GENETICS; INFECTION
- Publication
BMC Research Notes, 2010, Vol 3, p37
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/1756-0500-3-37