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- Title
A Comparative Study of Tricarbonylmanganese Photoactivatable CO Releasing Molecules (PhotoCORMs) by Using the Myoglobin Assay and Time-Resolved IR Spectroscopy.
- Authors
Huber, Wilhelm; Linder, Rolf; Niesel, Johanna; Schatzschneider, Ulrich; Spingler, Bernhard; Kunz, Peter C.
- Abstract
Tricarbonylmanganese(I) complexes of the ligands tris(imidazol-4-yl)phosphane (4-tipH), tris(1,4-diisopropylimidazol-2-yl)phosphane (2-tip iPr2), tris(pyridin-2-yl)phosphane (tpp) and tris( N-methylimidazol-2-yl)carbinol (2-ticNMe) were prepared. These act as N, N, N tripodal chelators. The solid-state structure of [Mn(CO)3(tpp)]OTf was determined by X-ray diffraction. The potential of these complexes to act as photoactivatable CO-releasing molecules (PhotoCORMs) was studied with the UV/Vis spectroscopy-based myoglobin assay as well as by time-resolved IR spectroscopy. Within the series of compounds prepared, the steric bulk of the imidazolyl groups seems to significantly influence the CO-release kinetics and stoichiometry when using the myoglobin assay. In contrast, the time-resolved IR data suggest release of all carbonyl ligands upon irradiation. This effect points to a much closer association of myoglobin and PhotoCORMs than previously thought and will require further investigation.
- Subjects
MANGANESE; CARBONYL compounds; CARBON monoxide; INFRARED spectroscopy; PHOSPHINES; MYOGLOBIN
- Publication
European Journal of Inorganic Chemistry, 2012, Vol 2012, Issue 20, p3140
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.201200115