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- Title
Antinociceptive profiles and mechanisms of orally administered vanillin in the mice.
- Authors
Park, Soo-Hyun; Sim, Yun-Beom; Choi, Seung-Min; Seo, Young-Jun; Kwon, Min-Soo; Lee, Jin-Koo; Suh, Hong-Won
- Abstract
In the present study, the antinociceptive profiles of vanillin were examined in ICR mice. Vanillin administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Duration of antinociceptive action of vanillin maintained at least for 30 min. But, the cumulative response time of nociceptive behaviors induced by a subcutaneous (s.c.) formalin injection, intrathecal (i.t.) substance P (0.7 µg) or glutamate (20 µg) injection was not affected by vanillin. Intraperitoneal (i.p.) pretreatment with yohimbine (α2-adrenergic receptor antagonist) or naloxone (opioid receptor antagonist) attenuated antinociceptive effect induced by vanillin in the writhing test. However, phentolamine (α1-adrenergic receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by vanillin in the writhing test. Our results suggest that vanillin exerts a selective antinociceptive property in the acetic acidinduced visceral inflammatory pain model. Furthermore, this antinociceptive effect of vanillin may be mediated by α2-adrenergic and opioid receptors, but not α1-adrenergic and serotonergic receptors.
- Publication
Archives of Pharmacal Research, 2009, Vol 32, Issue 11, p1643
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-009-2119-8