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- Title
Beneficial effect of renal transplantation on cognitive brain function.
- Authors
Kramer, Ludwig; Madl, Christian; Stockenhuber, Felix; Yeganehfar, Wafa; Eisenhuber, Edith; Derfler, Kurt; Lenz, Kurt; Schneider, Barbara; Grimm, Georg; Kramer, L; Madl, C; Stockenhuber, F; Yeganehfar, W; Eisenhuber, E; Derfler, K; Lenz, K; Schneider, B; Grimm, G
- Abstract
Cognitive brain dysfunction is a common complication of end-stage renal disease. To investigate the cerebral effect of renal transplantation, we studied P300 event-related potentials--an objective marker of cognitive brain function--trailmaking test and Mini-mental state in 15 chronic hemodialysis patients and 45 matched healthy subjects. Before transplantation, patients showed prolonged P300 latency (364 vs. 337 ms, P < 0.01), smaller amplitude (15.2 vs. 19.1 microV) and scored lower (P < 0.05) in trailmaking test and Mini-mental state as compared to healthy subjects. Following renal transplantation (14 months), P300 latency decreased (337 ms, P < 0.01 vs. before) and amplitude increased (17.4 microV, P < 0.05 vs. before), indicating improved cognitive brain function. The trailmaking test and Mini-mental state tended to improve. Following transplantation, P300 findings, trailmaking test and Mini-mental state were not different from healthy subjects. Additional studies following erythropoietin treatment in 6 of the 15 hemodialysis patients revealed decreased (improved) P300 latency (351 vs. 379 ms before, P < 0.05) with further decrease following transplantation (341 ms, P = 0.06). Our findings indicate that cognitive brain dysfunction in hemodialysis patients may be fully reversed by successful renal transplantation.
- Subjects
CHRONIC kidney failure; KIDNEY transplantation; BRAIN; HEMODIALYSIS patients; ERYTHROPOIETIN; THERAPEUTICS
- Publication
Kidney International, 1996, Vol 49, Issue 3, p833
- ISSN
0085-2538
- Publication type
journal article
- DOI
10.1038/ki.1996.115