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- Title
Multicenter retrospective study of the prognosis and the effect of postoperative adjuvant therapy in Japanese oral squamous cell carcinoma patients with close margin.
- Authors
Hasegawa, Takumi; Kakei, Yasumasa; Yamakawa, Nobuhiro; Kirita, Tadaaki; Okura, Masaya; Naruse, Tomofumi; Otsuru, Mitsunobu; Yamada, Shin‐ichi; Kurita, Hiroshi; Hirai, Eiji; Rin, Shin; Ueda, Michihiro; Umeda, Masahiro; Akashi, Masaya
- Abstract
Background: The purpose of this retrospective study was to investigate the prognosis of patients with oral cavity cancer with positive margin (PM) or close margin (CM) divided into pN− and pN+ groups. Methods: The evaluated endpoints were local control and disease‐specific survival (DSS) rates. Results: Higher T classification, lymphovascular space invasion (LVSI), and older age were significant risk factors for DSS in the pN− groups. On the other hand, extranodal extension, multiple lymph node metastases, and LVSI were significant risk factors for DSS in the pN+ groups. Among the CM pN+ patients, no significant differences in the 3‐year DSS were observed between the only surgery (51.9%) and adjuvant groups (53.2%). Conclusions: Higher T classification and LVSI are high‐risk features more than PM or CM in the pN− groups for DSS. However, further prospective studies are needed to demonstrate the usefulness of adjuvant treatment in patients with PM or CM.
- Subjects
SQUAMOUS cell carcinoma; LYMPHATIC metastasis; RETROSPECTIVE studies; ORAL cancer; PROGNOSIS
- Publication
Head & Neck, 2023, Vol 45, Issue 6, p1418
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27355