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- Title
Accuracy of fine‐needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta‐analysis.
- Authors
Costantino, Andrea; Mercante, Giuseppe; D'Ascoli, Elisa; Ferreli, Fabio; Di Tommaso, Luca; Franzese, Ciro; Giannitto, Caterina; Casale, Manuele; Spriano, Giuseppe; De Virgilio, Armando
- Abstract
Purpose: To define the accuracy of fine‐needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients. Methods: The study was performed according to the PRISMA‐DTA guidelines. Results: A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%‐80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%‐93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89‐38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3‐11.2) and 0.37 (95% CI: 0.22‐0.54), respectively. Conclusions: FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.
- Subjects
NEEDLE biopsy; METASTASIS; CYTOLOGY; NECK dissection; RADIOTHERAPY
- Publication
Head & Neck, 2021, Vol 43, Issue 3, p987
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26536