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- Title
Multicenter retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with level IV/V metastasis.
- Authors
Hasegawa, Takumi; Yanamoto, Souichi; Otsuru, Mitsunobu; Kakei, Yasumasa; Okura, Masaya; Yamakawa, Nobuhiro; Yamada, Shin‐Ichi; Ota, Yoshihide; Umeda, Masahiro; Kirita, Tadaaki; Kurita, Hiroshi; Ueda, Michihiro; Komori, Takahide
- Abstract
Background: The purpose of this study was to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma and level IV/V metastasis and to compare patients who underwent no postoperative therapy with those who underwent postoperative radiotherapy (RT) and concomitant chemoradiotherapy (CCRT). Methods: We evaluated 669 patients. Clinicopathological data, postoperative therapy, and clinical course were investigated. Results: Sixty‐one patients (9.1%) developed level IV/V metastasis. The 3‐year cumulative overall survival rates of patients with and without level IV/V metastasis were 47.3% and 64.3%, respectively. Tongue tumors, pN2 or N3 classification, and moderate or poor differentiation were significantly associated with the development of level IV/V metastasis. The surgery+RT/CCRT group was associated with better 3‐year cumulative disease‐specific survival and overall survival rates than the surgery only group. Conclusion: Adjuvant therapy (RT alone or CCRT) after surgery is recommended for patients with level IV/V metastasis.
- Subjects
SQUAMOUS cell carcinoma; TREATMENT effectiveness; METASTASIS; RETROSPECTIVE studies; RADIOTHERAPY; PROGNOSIS
- Publication
Head & Neck, 2019, Vol 41, Issue 7, p2256
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25672