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- Title
Development and Initial Testing of a Modified UroVysion-Based Fluorescence In Situ Hybridization Score for Prediction of Progression in Bladder Cancer.
- Authors
Kocsmár, Ildikó; Pajor, Gábor; Gyöngyösi, Benedek; Székely, Eszter; Varga, Márton; Kocsmár, Éva; Kenessey, István; Beöthe, Tamás; Süle, Norbert; Majoros, Attila; Szendrői, Attila; Nyírády, Péter; Kiss, András; Riesz, Péter; Lotz, Gábor
- Abstract
<bold>Objectives: </bold>Our aim was to predict progression of non-muscle-invasive bladder urothelial carcinomas (NMIUCs) into muscle-invasive disease by assessing cytogenetic abnormality of tumors with a new UroVysion scoring system.<bold>Methods: </bold>Seventy-five bladder cancer cases (including 57 NMIUCs) were classified according to the quantitatively assessed degree of UroVysion-detected chromosomal abnormalities into urine fluorescence in situ hybridization score (UFS) groups: UFS I, II, and III. Cox time-to-event, Kaplan-Meier, and C-statistics analyses were performed.<bold>Results: </bold>UFS proved to be an independent prognostic factor of progression-free survival (PFS) and time to progression (TTP). NMIUCs with UFS III had a 34.05-fold increased hazard for progression to muscle-invasive cancer (TTP; 95% confidence interval, 5.841-198.5; P < .001) in comparison with UFS I to II cases. The addition of UFS to conventional risk scores increased the C-index for PFS and TTP.<bold>Conclusions: </bold>UFS can indicate an increased risk for progression into muscle-invasive disease in patients with NMIUC and improves prognostic accuracy of the current clinical risk assessment systems.
- Subjects
BLADDER cancer; FLUORESCENCE in situ hybridization; CANCER invasiveness; TRANSITIONAL cell carcinoma; CYTOGENETICS; PROGRESSION-free survival; KIDNEY pelvis; BLADDER tumors; DISEASE progression; PROGNOSIS
- Publication
American Journal of Clinical Pathology, 2020, Vol 153, Issue 2, p274
- ISSN
0002-9173
- Publication type
journal article
- DOI
10.1093/ajcp/aqz165