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- Title
Issue Information.
- Abstract
B Front cover: b Mice lacking Shati, an N-acetyltransferase-8-like protein (Shati/Nat8l SP -/- sp ) have a series of changes in the dopamine system and attentional impairments. The ability of exosomes to transport proteins and genetic material between cells, including mRNA and microRNAs which have been implicated in PD pathology, provides critical insights as to how exosomes may contribute to pathological progression in PD. -synuclein abnormalities trigger focal tau pathology, spreading to various brain areas in Pa... I F. Hadi, H. Akrami, M. Totonchi, A. Barzegar, S. M. Nabavi and K. Shahpasand i We herein examined the development of -synuclein and tau pathology in Parkinson's disease (PD). MiR-3473b may regulate the secretion of proinflammatory mediators by targeting TREM2/ULK1 expression to regulate the role of autophagy in the pathogenesis of inflammation in Parkinson's disease, suggesting that mir-3473b may be a potential therapeutic target to regulate the inflammatory response in Parkinson disease.
- Subjects
DEVELOPMENTAL neurobiology; EXOSOMES; TAU proteins; CYTOLOGY; FRAGILE X syndrome; LONG-term synaptic depression; VITAMIN C deficiency
- Publication
Journal of Neurochemistry, 2021, Vol 157, Issue 3, p313
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/jnc.15061