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- Title
Sustained viral load and late death in Rag2-/- mice after influenza A virus infection.
- Authors
Haiya Wu; Haist, Verena; Baumgärtner, Wolfgang; Schughart, Klaus
- Abstract
The importance of the adaptive immune response for secondary influenza infections and protection from a lethal challenge after vaccination has been well documented. However, some controversy still exists concerning the specific involvement of B and T cells during a primary infection. Here, we have followed the survival, weight loss, viral load and lung pathology in Rag2-/- knock-out mice after infection with influenza A virus (H1N1). Infected wild type mice initially lost weight early after infection but then cleared the virus and recovered. Rag2-/- mice, however, showed similar weight loss kinetics in the early stages after infection but weight loss continued post infection and culminated in death. In contrast to wild type mice, Rag2-/- mice were not able to clear the virus, despite an increased inflammatory response. Furthermore, they did not recruit virus-specific lymphocytes into the lung in the later stages after infection and exhibited sustained pulmonary lesions.
- Subjects
VIRAL load; INFLUENZA; VIRUS diseases; VACCINATION; WEIGHT loss
- Publication
Virology Journal, 2010, Vol 7, p172
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/1743-422X-7-172