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- Title
Objective assessment of impulse control disorder in patients with Parkinson's disease using a low-cost LEGO-like EEG headset: a feasibility study.
- Authors
Lin, Yuan-Pin; Liang, Hsing-Yi; Chen, Yueh-Sheng; Lu, Cheng-Hsien; Wu, Yih-Ru; Chang, Yung-Yee; Lin, Wei-Che
- Abstract
<bold>Background: </bold>Patients with Parkinson's disease (PD) can develop impulse control disorders (ICDs) while undergoing a pharmacological treatment for motor control dysfunctions with a dopamine agonist (DA). Conventional clinical interviews or questionnaires can be biased and may not accurately diagnose at the early stage. A wearable electroencephalogram (EEG)-sensing headset paired with an examination procedure can be a potential user-friendly method to explore ICD-related signatures that can detect its early signs and progression by reflecting brain activity.<bold>Methods: </bold>A stereotypical Go/NoGo test that targets impulse inhibition was performed on 59 individuals, including healthy controls, patients with PD, and patients with PD diagnosed by ICDs. We conducted two Go/NoGo sessions before and after the DA-pharmacological treatment for the PD and ICD groups. A low-cost LEGO-like EEG headset was used to record concurrent EEG signals. Then, we used the event-related potential (ERP) analytical framework to explore ICD-related EEG abnormalities after DA treatment.<bold>Results: </bold>After the DA treatment, only the ICD-diagnosed PD patients made more behavioral errors and tended to exhibit the deterioration for the NoGo N2 and P3 peak amplitudes at fronto-central electrodes in contrast to the HC and PD groups. Particularly, the extent of the diminished NoGo-N2 amplitude was prone to be modulated by the ICD scores at Fz with marginal statistical significance (r = - 0.34, p = 0.07).<bold>Conclusions: </bold>The low-cost LEGO-like EEG headset successfully captured ERP waveforms and objectively assessed ICD in patients with PD undergoing DA treatment. This objective neuro-evidence could provide complementary information to conventional clinical scales used to diagnose ICD adverse effects.
- Subjects
IMPULSE control disorders; PARKINSON'S disease; ELECTROENCEPHALOGRAPHY; HEADSETS; EVOKED potentials (Electrophysiology); DIAGNOSIS
- Publication
Journal of NeuroEngineering & Rehabilitation (JNER), 2021, Vol 18, Issue 1, p1
- ISSN
1743-0003
- Publication type
journal article
- DOI
10.1186/s12984-021-00897-1