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- Title
Colorimetric and visual determination of uric acid based on decolorization of manganese dioxide nanosheet dispersions.
- Authors
Hu, Rongjing; Guo, Tianmin; Zeng, Chenyi; Fu, Xiaolong; Dong, Binhua; Lin, Zhenyu; Dong, Yongqiang; Fu, Fengfu
- Abstract
Serum levels of uric acid (UA) play an important role in the prevention of diseases. Developing a rapid and accurate way to detect UA is still a meaningful task. Hence, positively charged manganese dioxide nanosheets (MnO2NSs) with an average latter size of 100 nm and an ultra-thin thickness of below 1 nm have been prepared. They can be well dispersed in water and form stable yellow-brown solutions. The MnO2NSs can be decomposed by UA via redox reaction, leading to a decline of a characteristic absorption peak (374 nm) and a color fading of MnO2NSs solution. On this basis, an enzyme-free colorimetric sensing system for the detection of UA has been developed. The sensing system shows many advantages, including a wide linear range of 0.10–50.0 μmol/L, a limit of quantitation (LOQ) of 0.10 μmol/L, a low limit of detection (LOD) of 0.047 μmol/L (3σ/m), and rapid response without need of strict time control. Moreover, a simple and convenient visual sensor for UA detection has also been developed by adding an appropriate amount of phthalocyanine to provide a blue background color, which helps to increase visual discrimination. Finally, the strategy has been successfully applied to detect UA in human serum and urine samples.
- Subjects
MANGANESE dioxide; URIC acid; VISUAL discrimination; COPPER phthalocyanine; OXIDATION-reduction reaction; DISPERSION (Chemistry)
- Publication
Microchimica Acta, 2023, Vol 190, Issue 6, p1
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-023-05767-2